RESUMO
Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.
Assuntos
Vacinas contra COVID-19 , COVID-19 , Adulto , COVID-19/diagnóstico , COVID-19/prevenção & controle , Vacinas contra COVID-19/efeitos adversos , Feminino , Humanos , RNA Mensageiro , SARS-CoV-2 , Pele/patologiaAssuntos
Antirreumáticos , Artrite Reumatoide , Meningite Asséptica , Adalimumab/efeitos adversos , Antirreumáticos/efeitos adversos , Artrite Reumatoide/tratamento farmacológico , Humanos , Meningite Asséptica/induzido quimicamente , Meningite Asséptica/diagnóstico , Meningite Asséptica/tratamento farmacológicoAssuntos
Síndrome da Imunodeficiência Adquirida/patologia , Síndrome da Imunodeficiência Adquirida/virologia , Úlcera do Pé/patologia , Úlcera do Pé/virologia , Herpesvirus Humano 1 , Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , Aciclovir/análogos & derivados , Aciclovir/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Antivirais/uso terapêutico , Úlcera do Pé/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Valaciclovir , Valina/análogos & derivados , Valina/uso terapêuticoRESUMO
Hematogenous bone metastases from endometrial carcinoma are not frequent and their treatment is a matter of debate. We describe an extremely rare case of calvarial metastasis from endometrial carcinoma in an 80-year-old woman treated by means of one-step surgical radical resection and heterologous cranioplasty, along with a review of the literature regarding epidemiology, clinico-radiological features, prognosis, and management of skull metastases.
